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inhibitory hm4di receptors  (Matos labs)

 
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    Matos labs inhibitory hm4di receptors
    Inhibitory Hm4di Receptors, supplied by Matos labs, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/inhibitory+hm4di+receptors/inhibitory+hm4di+receptors/pm35654210-492-0-32
    Average 90 stars, based on 1 article reviews
    inhibitory hm4di receptors - by Bioz Stars, 2026-08
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    Figure 2. The mOFC!BLA pathway regulates the influence of stimulus-outcome memories over decision making and adaptive conditional responding. A, Schematic of behavioral training, testing, and chemogenetic inactivation strategy. CS, conditional stimulus (white noise or tone); O, outcome (sucrose solution or food pellet); A, action (left or right lever press). B, Representative fluorescent image of <t>hM4Di-mCherry</t> expression in mOFC cell bodies and immunofluorescent image of mOFC axons and terminals in the BLA near the implanted guide cannula. C, Schematic representation of hM4Di-mCherry expression in mOFC and axonal expression and injector tip placements in BLA for all subjects. D, Lever-press rate (lever presses/min) during the PIT test averaged across levers during the preCS baseline periods and during the CS periods on the lever earning the same outcome as the presented CS and the alternate lever (Different). Data are averaged across trials and CSs. E, Rate of entries into the food-delivery port (food-port entries/min) during the PIT test for the preCS baseline periods and during CS presentation (averaged across trials and CSs). F, Average lever-press rate during the instrumental choice phase of the outcome-specific devaluation test. Presses separated for those on the action that in training earned the valued versus devalued (prefed) reward. G, Rate of entries into the food-delivery port during the outcome-specific devaluation test, averaged across trials, during the preCS baseline period, and during presentation of the CS predicting the valued and devalued (prefed) rewards. Lines represent individual subjects. *p , 0.05, **p , 0.01, ***p , 0.001.
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    Figure 2. The mOFC!BLA pathway regulates the influence of stimulus-outcome memories over decision making and adaptive conditional responding. A, Schematic of behavioral training, testing, and chemogenetic inactivation strategy. CS, conditional stimulus (white noise or tone); O, outcome (sucrose solution or food pellet); A, action (left or right lever press). B, Representative fluorescent image of <t>hM4Di-mCherry</t> expression in mOFC cell bodies and immunofluorescent image of mOFC axons and terminals in the BLA near the implanted guide cannula. C, Schematic representation of hM4Di-mCherry expression in mOFC and axonal expression and injector tip placements in BLA for all subjects. D, Lever-press rate (lever presses/min) during the PIT test averaged across levers during the preCS baseline periods and during the CS periods on the lever earning the same outcome as the presented CS and the alternate lever (Different). Data are averaged across trials and CSs. E, Rate of entries into the food-delivery port (food-port entries/min) during the PIT test for the preCS baseline periods and during CS presentation (averaged across trials and CSs). F, Average lever-press rate during the instrumental choice phase of the outcome-specific devaluation test. Presses separated for those on the action that in training earned the valued versus devalued (prefed) reward. G, Rate of entries into the food-delivery port during the outcome-specific devaluation test, averaged across trials, during the preCS baseline period, and during presentation of the CS predicting the valued and devalued (prefed) rewards. Lines represent individual subjects. *p , 0.05, **p , 0.01, ***p , 0.001.
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    Image Search Results


    Figure 2. The mOFC!BLA pathway regulates the influence of stimulus-outcome memories over decision making and adaptive conditional responding. A, Schematic of behavioral training, testing, and chemogenetic inactivation strategy. CS, conditional stimulus (white noise or tone); O, outcome (sucrose solution or food pellet); A, action (left or right lever press). B, Representative fluorescent image of hM4Di-mCherry expression in mOFC cell bodies and immunofluorescent image of mOFC axons and terminals in the BLA near the implanted guide cannula. C, Schematic representation of hM4Di-mCherry expression in mOFC and axonal expression and injector tip placements in BLA for all subjects. D, Lever-press rate (lever presses/min) during the PIT test averaged across levers during the preCS baseline periods and during the CS periods on the lever earning the same outcome as the presented CS and the alternate lever (Different). Data are averaged across trials and CSs. E, Rate of entries into the food-delivery port (food-port entries/min) during the PIT test for the preCS baseline periods and during CS presentation (averaged across trials and CSs). F, Average lever-press rate during the instrumental choice phase of the outcome-specific devaluation test. Presses separated for those on the action that in training earned the valued versus devalued (prefed) reward. G, Rate of entries into the food-delivery port during the outcome-specific devaluation test, averaged across trials, during the preCS baseline period, and during presentation of the CS predicting the valued and devalued (prefed) rewards. Lines represent individual subjects. *p , 0.05, **p , 0.01, ***p , 0.001.

    Journal: The Journal of Neuroscience

    Article Title: The Medial Orbitofrontal Cortex–Basolateral Amygdala Circuit Regulates the Influence of Reward Cues on Adaptive Behavior and Choice

    doi: 10.1523/jneurosci.0901-21.2021

    Figure Lengend Snippet: Figure 2. The mOFC!BLA pathway regulates the influence of stimulus-outcome memories over decision making and adaptive conditional responding. A, Schematic of behavioral training, testing, and chemogenetic inactivation strategy. CS, conditional stimulus (white noise or tone); O, outcome (sucrose solution or food pellet); A, action (left or right lever press). B, Representative fluorescent image of hM4Di-mCherry expression in mOFC cell bodies and immunofluorescent image of mOFC axons and terminals in the BLA near the implanted guide cannula. C, Schematic representation of hM4Di-mCherry expression in mOFC and axonal expression and injector tip placements in BLA for all subjects. D, Lever-press rate (lever presses/min) during the PIT test averaged across levers during the preCS baseline periods and during the CS periods on the lever earning the same outcome as the presented CS and the alternate lever (Different). Data are averaged across trials and CSs. E, Rate of entries into the food-delivery port (food-port entries/min) during the PIT test for the preCS baseline periods and during CS presentation (averaged across trials and CSs). F, Average lever-press rate during the instrumental choice phase of the outcome-specific devaluation test. Presses separated for those on the action that in training earned the valued versus devalued (prefed) reward. G, Rate of entries into the food-delivery port during the outcome-specific devaluation test, averaged across trials, during the preCS baseline period, and during presentation of the CS predicting the valued and devalued (prefed) rewards. Lines represent individual subjects. *p , 0.05, **p , 0.01, ***p , 0.001.

    Article Snippet: Rats (N = 9, final) were infused bilaterally with AAV expressing the inhibitory designer receptor hM4Di (AAV8-hSyn-hM4Di-mCherry, 4.8 1012 or 3.7 1012 vg/ml; Addgene; 0.4mL) at a rate of 0.1mL/min into the BLA (AP: 3.0, ML: 65.1, DV: 8.6 mm from bregma) using a 33 gauge injector.

    Techniques: Expressing

    Figure 3. The BLA!mOFC pathway regulates adaptive cue responses based on predicted reward value. A, Schematic of behavioral training, testing, and chemogenetic inactivation strategy. CS, conditional stimulus (white noise or tone); O, outcome (sucrose solution or food pellet); A, action (left or right lever press). B, Representative fluorescent image of hM4Di-mCherry expression in cell bodies of the BLA and immunofluorescent image of BLA axons and terminals in the mOFC near the implanted guide cannula. C, Schematic representation of hM4Di-mCherry expression in BLA and axonal expression and injector tip placements in mOFC for all subjects. D, Lever-press rate (lever presses/min) during the PIT test averaged across levers during the preCS baseline periods and during the CS periods on the lever earning the same outcome as the presented CS and the alternate lever (Different). Data are averaged across trials and CSs. E, Rate of entries into the food-delivery port (food-port entries/min) during the PIT test for the preCS baseline periods and during CS presentation (averaged across trials and CSs). F, Average lever-press rate during the instrumental phase of the outcome-specific devaluation test. Presses separated for those on the action that in training earned the valued versus devalued (prefed) reward. G, Rate of entries into the food-delivery port during the outcome-specific devaluation test, averaged across trials, during the preCS baseline period, and during presentation of the CS predicting the valued and devalued (prefed) rewards. Lines represent individual subjects. *p , 0.05, **p , 0.01.

    Journal: The Journal of Neuroscience

    Article Title: The Medial Orbitofrontal Cortex–Basolateral Amygdala Circuit Regulates the Influence of Reward Cues on Adaptive Behavior and Choice

    doi: 10.1523/jneurosci.0901-21.2021

    Figure Lengend Snippet: Figure 3. The BLA!mOFC pathway regulates adaptive cue responses based on predicted reward value. A, Schematic of behavioral training, testing, and chemogenetic inactivation strategy. CS, conditional stimulus (white noise or tone); O, outcome (sucrose solution or food pellet); A, action (left or right lever press). B, Representative fluorescent image of hM4Di-mCherry expression in cell bodies of the BLA and immunofluorescent image of BLA axons and terminals in the mOFC near the implanted guide cannula. C, Schematic representation of hM4Di-mCherry expression in BLA and axonal expression and injector tip placements in mOFC for all subjects. D, Lever-press rate (lever presses/min) during the PIT test averaged across levers during the preCS baseline periods and during the CS periods on the lever earning the same outcome as the presented CS and the alternate lever (Different). Data are averaged across trials and CSs. E, Rate of entries into the food-delivery port (food-port entries/min) during the PIT test for the preCS baseline periods and during CS presentation (averaged across trials and CSs). F, Average lever-press rate during the instrumental phase of the outcome-specific devaluation test. Presses separated for those on the action that in training earned the valued versus devalued (prefed) reward. G, Rate of entries into the food-delivery port during the outcome-specific devaluation test, averaged across trials, during the preCS baseline period, and during presentation of the CS predicting the valued and devalued (prefed) rewards. Lines represent individual subjects. *p , 0.05, **p , 0.01.

    Article Snippet: Rats (N = 9, final) were infused bilaterally with AAV expressing the inhibitory designer receptor hM4Di (AAV8-hSyn-hM4Di-mCherry, 4.8 1012 or 3.7 1012 vg/ml; Addgene; 0.4mL) at a rate of 0.1mL/min into the BLA (AP: 3.0, ML: 65.1, DV: 8.6 mm from bregma) using a 33 gauge injector.

    Techniques: Expressing